BDBM272795 6-benzyl-3-(2-methylpyridin-4-yl)-1,8-dihydro-7H-pyrazolo[4,3-g]quinolin-7-one::US10065967, Example 3::US10301317, Example 6::US10759805, Ex 3::US9624228, Example 6::US9745307, Example 3

SMILES Cc1cc(ccn1)-c1n[nH]c2cc3[nH]c(=O)c(Cc4ccccc4)cc3cc12

InChI Key InChIKey=YJBIKMFGFQOJLA-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 272795   

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM272795(6-benzyl-3-(2-methylpyridin-4-yl)-1,8-dihydro-7H-p...)
Affinity DataIC50: 0.200nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Kura Oncology

US Patent
LigandPNGBDBM272795(6-benzyl-3-(2-methylpyridin-4-yl)-1,8-dihydro-7H-p...)
Affinity DataIC50: 150nMAssay Description:The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Kura Oncology

US Patent
LigandPNGBDBM272795(6-benzyl-3-(2-methylpyridin-4-yl)-1,8-dihydro-7H-p...)
Affinity DataIC50: 150nMAssay Description:The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Kura Oncology

US Patent
LigandPNGBDBM272795(6-benzyl-3-(2-methylpyridin-4-yl)-1,8-dihydro-7H-p...)
Affinity DataIC50: 200nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM272795(6-benzyl-3-(2-methylpyridin-4-yl)-1,8-dihydro-7H-p...)
Affinity DataIC50: 200nMAssay Description:Mouse: Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2021
Entry Details
US Patent