BDBM274261 6-(4-chlorophenyl)-5-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-2-(6-methoxypyridin-3-yl)-1-methyl-5,6-dihydropyrrolo[3,4-b]pyrrol-4(1H)-one::US9550796, Example 58

SMILES COc1ccc(cn1)-c1cc2C(=O)N(C(c2n1C)c1ccc(Cl)cc1)c1cc(C)c(=O)n(C)c1

InChI Key InChIKey=IMBCMESWDHPIDA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 274261   

TargetBromodomain-containing protein 4 [44-477](Human)
Novartis

US Patent
LigandPNGBDBM274261(6-(4-chlorophenyl)-5-(1,5-dimethyl-6-oxo-1,6-dihyd...)
Affinity DataIC50: 42nMpH: 7.5Assay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent

TargetBromodomain-containing protein 2 [60-463](Human)
Novartis

US Patent
LigandPNGBDBM274261(6-(4-chlorophenyl)-5-(1,5-dimethyl-6-oxo-1,6-dihyd...)
Affinity DataIC50: 40nMpH: 7.5Assay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent

TargetBromodomain-containing protein 3(Human)
Novartis

US Patent
LigandPNGBDBM274261(6-(4-chlorophenyl)-5-(1,5-dimethyl-6-oxo-1,6-dihyd...)
Affinity DataIC50: 34nMpH: 7.5Assay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent