BDBM274280 5-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-1-methyl-6-(p-tolyl)-5,6-dihydropyrrolo[3,4-b]pyrrol-4(1H)-one::US9550796, Example 81

SMILES Cc1ccc(cc1)C1N(C(=O)c2ccn(C)c12)c1cc(C)c(=O)n(C)c1

InChI Key InChIKey=NHUYOZGLCLQXEB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 274280   

TargetBromodomain-containing protein 3(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 274280BDBM274280(5-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-1-m...)
Affinity DataIC50: 81.2nMpH: 7.5Assay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetBromodomain-containing protein 2 [60-463](Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 274280BDBM274280(5-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-1-m...)
Affinity DataIC50: 126nMpH: 7.5Assay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetBromodomain-containing protein 4 [44-477](Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 274280BDBM274280(5-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-1-m...)
Affinity DataIC50: 131nMpH: 7.5Assay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetCREB-binding protein(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 274280BDBM274280(5-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-1-m...)
Affinity DataIC50: 4.50E+3nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent