BDBM274283 5-(1,5-di methyl-6-oxo-1,6-dihydropyridin-3-yl)-6-(4-methoxyphenyl)-1-methyl-5,6-dihydropyrrolo[3,4-b]pyrrol-4(1H)-one::US9550796, Example 84

SMILES COc1ccc(cc1)C1N(C(=O)c2ccn(C)c12)c1cc(C)c(=O)n(C)c1

InChI Key InChIKey=GAORTSKVVPSHRF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 274283   

TargetBromodomain-containing protein 3(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 274283BDBM274283(5-(1,5-di methyl-6-oxo-1,6-dihydropyridin-3-yl)-6-...)
Affinity DataIC50: 161nMpH: 7.5Assay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetBromodomain-containing protein 2 [60-463](Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 274283BDBM274283(5-(1,5-di methyl-6-oxo-1,6-dihydropyridin-3-yl)-6-...)
Affinity DataIC50: 196nMpH: 7.5Assay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetBromodomain-containing protein 4 [44-477](Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 274283BDBM274283(5-(1,5-di methyl-6-oxo-1,6-dihydropyridin-3-yl)-6-...)
Affinity DataIC50: 230nMpH: 7.5Assay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetCREB-binding protein(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 274283BDBM274283(5-(1,5-di methyl-6-oxo-1,6-dihydropyridin-3-yl)-6-...)
Affinity DataIC50: 4.70E+3nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent