BDBM274521 (S)-2,6-difluoro-N-(6-(4-(4- fluorophenyl)-1-(1-(3,3,3-trifluoro-2- hydroxypropyl)piperidin-4-yl)-1H- imidazol-5-yl)imidazo[1,2-b]pyridazin- 2-yl)isonicotinamide::US9556179, Compound 91

SMILES O[C@@H](CN1CCC(CC1)n1cnc(c1-c1ccc2nc(NC(=O)c3cc(F)nc(F)c3)cn2n1)-c1ccc(F)cc1)C(F)(F)F

InChI Key InChIKey=ZQFCYXGWCWXHJB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 274521   

TargetCasein kinase I isoform delta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM274521((S)-2,6-difluoro-N-(6-(4-(4- fluorophenyl)-1-(1-(3...)
Affinity DataIC50: 0.296nMpH: 7.4 T: 2°CAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetCasein kinase I isoform epsilon(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM274521((S)-2,6-difluoro-N-(6-(4-(4- fluorophenyl)-1-(1-(3...)
Affinity DataIC50: 0.796nMpH: 7.4 T: 2°CAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent