BDBM274663 2-fluoro-N-(6-(1-(2-fluoroethyl)-4- (4-fluorophenyl)-1H-imidazol-5-yl) imidazo[1,2-b]pyridazin-2-yl)iso- nicotinamide::US9556179, Compound 238

SMILES FCCn1cnc(c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1)-c1ccc(F)cc1

InChI Key InChIKey=MWRGKCVRCVYKRF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 274663   

TargetCasein kinase I isoform delta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM274663(2-fluoro-N-(6-(1-(2-fluoroethyl)-4- (4-fluoropheny...)
Affinity DataIC50: 0.223nMpH: 7.4 T: 2°CAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetCasein kinase I isoform epsilon(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM274663(2-fluoro-N-(6-(1-(2-fluoroethyl)-4- (4-fluoropheny...)
Affinity DataIC50: 0.412nMpH: 7.4 T: 2°CAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent