BDBM274911 US9556190, Example 2::US9556190, Example 6

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1c(F)cccc1-n1nccn1)Oc1nccc2c1C(=O)OC2(C)C

InChI Key InChIKey=XANYTJDTUQHRGD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 274911   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM274911(US9556190, Example 6 | US9556190, Example 2)
Affinity DataIC50: 13nMAssay Description: In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM274911(US9556190, Example 6 | US9556190, Example 2)
Affinity DataIC50: 44nMAssay Description: In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM274911(US9556190, Example 6 | US9556190, Example 2)
Affinity DataIC50: 2.71E+3nMAssay Description: In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM274911(US9556190, Example 6 | US9556190, Example 2)
Affinity DataIC50: 1.00E+4nMAssay Description: In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent