BDBM274921 4-{[(3R,6R)-1-{[4-methoxy-2-(2H- 1,2,3-triazol-2-yl)phenyl]carbonyl}-6- methylpiperidin-3-yl]oxy}-1,1- dimethylfuro[3,4-c]pyridin-3(1H)-one::US9556190, Example 11

SMILES COc1ccc(C(=O)N2C[C@@H](CC[C@H]2C)Oc2nccc3c2C(=O)OC3(C)C)c(c1)-n1nccn1

InChI Key InChIKey=BWIFWEXLHLCBAL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 274921   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM274921(4-{[(3R,6R)-1-{[4-methoxy-2-(2H- 1,2,3-triazol-2-y...)
Affinity DataIC50: 147nMAssay Description: In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM274921(4-{[(3R,6R)-1-{[4-methoxy-2-(2H- 1,2,3-triazol-2-y...)
Affinity DataIC50: 1.00E+4nMAssay Description: In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent