BDBM274941 1-[2-({(2R,5R)-2- methyl-5-[(1-oxo- 1,3-dihydrofuro[3,4- c]pyridin-4-yl)oxy]- piperidin-1-yl}- carbonyl)- phenyl]cyclo- propane- carbonitrile::US9556190, Example 31

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1C1(CC1)C#N)Oc1nccc2C(=O)OCc12

InChI Key InChIKey=YOYHOMQHRBFXIN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 274941   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM274941(1-[2-({(2R,5R)-2- methyl-5-[(1-oxo- 1,3-dihydrofur...)
Affinity DataIC50: 12nMAssay Description: In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM274941(1-[2-({(2R,5R)-2- methyl-5-[(1-oxo- 1,3-dihydrofur...)
Affinity DataIC50: 1.78E+3nMAssay Description: In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent