BDBM274953 1,1-dimethyl-4- {[(3R,6R)-6-methyl- 1-{[2-(2H-1,2,3- triazol-2- yl)thiophen-3-yl]- carbonyl}piperidin- 3-yl]amino}- furo[3,4-c]pyridin- 3(1H)-one::US9556190, Example 43

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccsc1-n1nccn1)Nc1nccc2c1C(=O)OC2(C)C

InChI Key InChIKey=TXDXIBOCOVEFDY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 274953   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM274953(1,1-dimethyl-4- {[(3R,6R)-6-methyl- 1-{[2-(2H-1,2,...)
Affinity DataIC50: 19nMAssay Description: In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM274953(1,1-dimethyl-4- {[(3R,6R)-6-methyl- 1-{[2-(2H-1,2,...)
Affinity DataIC50: 1.00E+4nMAssay Description: In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent