BDBM274965 N-((2-(tert-butylcarbamoyl)-5-(3- methoxyphenyl)-1,2,3,4- tetrahydroisoquinolin-8- yl)methyl)isoquinoline-1-carboxamide::US9877957, Example 5

SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2nccc3ccccc23)c2CN(CCc12)C(=O)NC(C)(C)C

InChI Key InChIKey=YENDNBGZJSCYIV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 274965   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM274965(N-((2-(tert-butylcarbamoyl)-5-(3- methoxyphenyl)-1...)
Affinity DataIC50: 135nMpH: 7.0 T: 2°CAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent