BDBM276010 US10071974, Example 121::US10071974, Example 122::US10577336, Example 122

SMILES Cc1nc(n2cccc(F)c12)C(C)(C)NC(=O)C1CNCCOC1

InChI Key InChIKey=BHUONHWTHYGRRP-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 276010   

TargetSomatostatin receptor type 4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM276010(US10071974, Example 122 | US10071974, Example 121 ...)
Affinity DataEC50:  11.1nMpH: 7.4 T: 2°CAssay Description:Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetSomatostatin receptor type 4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM276010(US10071974, Example 122 | US10071974, Example 121 ...)
Affinity DataEC50:  11.1nMAssay Description:The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent

TargetSomatostatin receptor type 4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM276010(US10071974, Example 122 | US10071974, Example 121 ...)
Affinity DataEC50:  1.00E+3nMpH: 7.4 T: 2°CAssay Description:Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetSomatostatin receptor type 4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM276010(US10071974, Example 122 | US10071974, Example 121 ...)
Affinity DataEC50:  1.00E+3nMAssay Description:The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent