BDBM276526 2-[2-[[1-(3-Fluoro-2-methyl-phenyl)triazol-4-yl]methoxy]pyrimidin-5-::US10071988, Example 466::US10233173, Example 466

SMILES C[C@@H]1CCCOc2ccccc2-c2cc(ccn2)C(=O)/N=C2\Nc3ccccc3N2C1

InChI Key InChIKey=FEVMAVZPYZRGHW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 276526   

TargetEpidermal growth factor receptor [1-745,751-1210,T790M,C797S](Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 276526BDBM276526(US12522615, Example I-046)
Affinity DataIC50: 1.30nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [695-1022,T790M,C797S,L858R](Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 276526BDBM276526(US12522615, Example I-046)
Affinity DataIC50: 1.80nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [695-1022,T790M,C797S,L858R](Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 276526BDBM276526(US12522615, Example I-046)
Affinity DataIC50: 16nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2026
Entry Details US Patent

TargetEpidermal growth factor receptor(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 276526BDBM276526(US12522615, Example I-046)
Affinity DataIC50: 18nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2026
Entry Details US Patent

TargetEpidermal growth factor receptor(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 276526BDBM276526(US12522615, Example I-046)
Affinity DataIC50: 1.00E+5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2026
Entry Details US Patent