BDBM276800 (R)-5-(5-(((R)-3-chloro-6,7-dihydro-5H-cyc1openta[b]pyridin-5-yl)amino)-2-fluorophenyl)-3-imino-2,5-dimethyl-1,2,4-thiadiazinane 1,1-dioxide::US10071998, Example 15

SMILES CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(N[C@@H]2CCc3ncc(Cl)cc23)ccc1F

InChI Key InChIKey=AWMWBVLHSLMMBZ-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 276800   

TargetBeta-secretase 1(Human)
TBA

US Patent
LigandPNGBDBM276800((R)-5-(5-(((R)-3-chloro-6,7-dihydro-5H-cyc1openta[...)
Affinity DataKi:  41.2nMpH: 5.0Assay Description:The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetBeta-secretase 2(Human)
TBA

US Patent
LigandPNGBDBM276800((R)-5-(5-(((R)-3-chloro-6,7-dihydro-5H-cyc1openta[...)
Affinity DataKi:  124nMpH: 5.0Assay Description:Inhibitor IC50s, at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent