BDBM277336 US10072025, Example 2-14::tert-butyl 4-ethyl-4-(3-((3- methyl-4-(2-oxa-6- azaspiro[3.3]heptane-6- carbonyl)phenyl) amino)- 4-oxo-4,5-dihydro-1H- pyrazolo [4,3-c]pyridin-1- yl) piperidine-1- carboxylate

SMILES CCC1(CCN(CC1)C(=O)OC(C)(C)C)n1nc(Nc2ccc(C(=O)N3CC4(COC4)C3)c(C)c2)c2c1cc[nH]c2=O

InChI Key InChIKey=HREQEXVKQFAMSO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 277336   

TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM277336(US10072025, Example 2-14 | tert-butyl 4-ethyl-4-(3...)
Affinity DataIC50: 0.300nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM277336(US10072025, Example 2-14 | tert-butyl 4-ethyl-4-(3...)
Affinity DataIC50: 0.430nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent