BDBM277337 US10072025, Example 2-15::tert-butyl 4-(3-((4- ((1R,4R)-2-oxa-5- azabicyclo[2.2.1]heptane- 5-carbonyl)-3- methylphenyl)amino)-4- oxo-4,5-dihydro-1H- pyrazolo[4,3-c]pyridin-1- yl)-4-ethylpiperidine-1- carboxylate

SMILES [H][C@@]12CN(C(=O)c3ccc(Nc4nn(c5cc[nH]c(=O)c45)C4(CC)CCN(CC4)C(=O)OC(C)(C)C)cc3C)[C@@]([H])(CO1)C2

InChI Key InChIKey=XKLMPWQCHSGFNF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 277337   

TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM277337(US10072025, Example 2-15 | tert-butyl 4-(3-((4- ((...)
Affinity DataIC50: 0.400nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM277337(US10072025, Example 2-15 | tert-butyl 4-(3-((4- ((...)
Affinity DataIC50: 0.430nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent