BDBM277338 (S or R)-tert-butyl-4-ethyl- 4-(4-oxo-3-((4-(2- (trifluoromethyl) azepan- 2-yl)phenyl) amino)-4,5- dihydro-1H-pyrazolo[4,3- c]pyridin-1-yl) piperidine- 1-carboxylate::US10072025, Example 2-16

SMILES CCC1(CCN(CC1)C(=O)OC(C)(C)C)n1nc(Nc2ccc(cc2)[C@@]2(CCCCCN2)C(F)(F)F)c2c1cc[nH]c2=O

InChI Key InChIKey=PWYKXEFCCILMII-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 277338   

TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 277338BDBM277338(US10072025, Example 2-16 | (S or R)-tert-butyl-4-e...)
Affinity DataIC50: 8.85nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 277338BDBM277338(US10072025, Example 2-16 | (S or R)-tert-butyl-4-e...)
Affinity DataIC50: 10.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent