BDBM277344 US10072025, Example 2-22::tert-butyl 4-(3-(4-((1S,4S)- 5-oxa-2-aza- bicyclo[2.2.1]heptane-2- carbonyl)-3- methylphenylamino)-4- oxo-4,5- dihydropyrazolo[4,3- c]pyridin-1-yl)-4- ethylpiperidine-1- carboxylate

SMILES [H][C@]12CN(C(=O)c3ccc(Nc4nn(c5cc[nH]c(=O)c45)C4(CC)CCN(CC4)C(=O)OC(C)(C)C)cc3C)[C@]([H])(CO1)C2

InChI Key InChIKey=XKLMPWQCHSGFNF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 277344   

TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM277344(US10072025, Example 2-22 | tert-butyl 4-(3-(4-((1S...)
Affinity DataIC50: 0.360nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM277344(US10072025, Example 2-22 | tert-butyl 4-(3-(4-((1S...)
Affinity DataIC50: 0.440nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent