BDBM277352 US10072025, Example 2-30::tert-butyl 4-ethyl-4-(3-((2- (1-methyl piperidin-4-yl)- 1,1-dioxido-2,3- dihydrobenzo [d] isothiazol-5-yl) amino)-4- oxo-4,5-dihydro-1H- pyrazolo [4,3-c]pyridin-1- yl) piperidine-1- carboxylate

SMILES CCC1(CCN(CC1)C(=O)OC(C)(C)C)n1nc(Nc2ccc3c(CN(C4CCN(C)CC4)S3(=O)=O)c2)c2c1cc[nH]c2=O

InChI Key InChIKey=SBQHJPSEAQKYTP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 277352   

TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM277352(US10072025, Example 2-30 | tert-butyl 4-ethyl-4-(3...)
Affinity DataIC50: 0.290nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM277352(US10072025, Example 2-30 | tert-butyl 4-ethyl-4-(3...)
Affinity DataIC50: 0.360nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent