BDBM277513 US10072026, Example 4-4::US10947254, Example 4-4::US11780852, Example 4-4

SMILES Cc1cc(Nc2cc3ncccc3c(N[C@@H]3C[C@H]4CC[C@@H](C3)N4S(=O)(=O)C3CC3)n2)n[nH]1

InChI Key InChIKey=GVJIRRDTPDEOQN-UHFFFAOYSA-N

Data  12 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 277513   

TargetTyrosine-protein kinase JAK1(Human)
Theravance Biopharma R&D IP

US Patent
LigandChemical structure of BindingDB Monomer ID 277513BDBM277513(US10072026, Example 4-4 | US10947254, Example 4-4 ...)
Affinity DataKi:  0.550nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Theravance Biopharma R&D IP

US Patent
LigandChemical structure of BindingDB Monomer ID 277513BDBM277513(US10072026, Example 4-4 | US10947254, Example 4-4 ...)
Affinity DataKi:  0.550nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Theravance Biopharma R&D IP

US Patent
LigandChemical structure of BindingDB Monomer ID 277513BDBM277513(US10072026, Example 4-4 | US10947254, Example 4-4 ...)
Affinity DataKi:  50.5nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2025
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Theravance Biopharma R&D IP

US Patent
LigandChemical structure of BindingDB Monomer ID 277513BDBM277513(US10072026, Example 4-4 | US10947254, Example 4-4 ...)
Affinity DataKi:  50.5nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2025
Entry Details
US Patent