BDBM277771 3-{[5-fluoro-1-(tetrahydrofuran-3-yl)-1H-indol-3-yl]amino}pyridine-4-carboxylic acid::US10040779, Example 68::US10336727, Example 68

SMILES OC(=O)c1ccncc1Nc1cn(C2CCOC2)c2ccc(F)cc12

InChI Key InChIKey=HLHPSEPZDHRQDS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 277771   

TargetLysine-specific demethylase 5A(Human)
Celgene Quanticel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 277771BDBM277771(3-{[5-fluoro-1-(tetrahydrofuran-3-yl)-1H-indol-3-y...)
Affinity DataIC50: 100nMAssay Description:The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetLysine-specific demethylase 5B(Human)
Celgene Quanticel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 277771BDBM277771(3-{[5-fluoro-1-(tetrahydrofuran-3-yl)-1H-indol-3-y...)
Affinity DataIC50: 100nMAssay Description:The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 277771BDBM277771(3-{[5-fluoro-1-(tetrahydrofuran-3-yl)-1H-indol-3-y...)
Affinity DataIC50: 550nMAssay Description:The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent