BDBM278257 2-(((S)-1-((S)-2,3-dihydroxypropanoyl)-3,3-difluoropiperidin-4-yl)oxy)-5-(4-((2-methoxypyridin-4-yl)amino)-1,3,5-triazin-2-yl)benzonitrile::US10040781, Example 479::US10253019, Example 479

SMILES COc1cc(Nc2ncnc(n2)-c2ccc(O[C@H]3CCN(CC3(F)F)C(=O)[C@@H](O)CO)c(c2)C#N)ccn1

InChI Key InChIKey=IAQRFOBNZQJZEU-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 278257   

LigandPNGBDBM278257(2-(((S)-1-((S)-2,3-dihydroxypropanoyl)-3,3-difluor...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase TBK1(Human)
Gilead Sciences

US Patent
LigandPNGBDBM278257(2-(((S)-1-((S)-2,3-dihydroxypropanoyl)-3,3-difluor...)
Affinity DataIC50: 2nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Gilead Sciences

US Patent
LigandPNGBDBM278257(2-(((S)-1-((S)-2,3-dihydroxypropanoyl)-3,3-difluor...)
Affinity DataIC50: 1.00E+3nMAssay Description:Enzymatic activity of hJAK2 was measured using a LANCE homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that monitors...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

LigandPNGBDBM278257(2-(((S)-1-((S)-2,3-dihydroxypropanoyl)-3,3-difluor...)
Affinity DataIC50: 1.00E+3nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetSerine/threonine-protein kinase TBK1(Human)
Gilead Sciences

US Patent
LigandPNGBDBM278257(2-(((S)-1-((S)-2,3-dihydroxypropanoyl)-3,3-difluor...)
Affinity DataIC50: 2.00E+3nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Gilead Sciences

US Patent
LigandPNGBDBM278257(2-(((S)-1-((S)-2,3-dihydroxypropanoyl)-3,3-difluor...)
Affinity DataIC50: 1.00E+6nMpH: 7.5Assay Description:Enzymatic activity of hJAK2 was measured using a LANCE homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that monitors...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent