BDBM278546 (2E)-[1-{[5-(3-Methyloxetan-3-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-3,4-dihydrobenzo[cd]indol-5(1H)-ylidene]ethanoic acid ::US10040791, Example 8

SMILES CC1(COC1)c1onc(c1C(=O)n1cc2CC\C(=C/C(O)=O)c3cccc1c23)-c1c(Cl)cc(Cl)cc1Cl

InChI Key InChIKey=YTFZGEAFVYSQNL-NTUHNPAUSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 278546   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132C](Human)
Daiichi Sankyo

US Patent
LigandPNGBDBM278546( (2E)-[1-{[5-(3-Methyloxetan-3-yl)-3-(2,4,6-trichl...)
Affinity DataIC50:  55nMpH: 7.5 T: 25°CAssay Description:The IDH1R132H protein and the IDH1R132C protein were prepared as follows: the IDH1R132H or IDH1R132C gene was integrated into a pET24b(+) vector (Nov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Daiichi Sankyo

US Patent
LigandPNGBDBM278546( (2E)-[1-{[5-(3-Methyloxetan-3-yl)-3-(2,4,6-trichl...)
Affinity DataIC50:  8nMpH: 7.5 T: 25°CAssay Description:The IDH1R132H protein and the IDH1R132C protein were prepared as follows: the IDH1R132H or IDH1R132C gene was integrated into a pET24b(+) vector (Nov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent