BDBM278622 (2E)-3-[3-Methyl-1-({5-[2- (methylamino)propan-2-yl]-3- (2,4,6-trichlorophenyl)-1,2- oxazol-4-yl]carbonyl}-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 84

SMILES CNC(C)(C)c1onc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl

InChI Key InChIKey=JGTKFHUTIOMNMG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 278622   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Daiichi Sankyo

US Patent
LigandPNGBDBM278622((2E)-3-[3-Methyl-1-({5-[2- (methylamino)propan-2-y...)
Affinity DataIC50: 15nMpH: 7.5 T: 2°CAssay Description:The IDH1R132H protein and the IDH1R132C protein were prepared as follows: the IDH1R132H or IDH1R132C gene was integrated into a pET24b(+) vector (Nov...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132C](Human)
Daiichi Sankyo

US Patent
LigandPNGBDBM278622((2E)-3-[3-Methyl-1-({5-[2- (methylamino)propan-2-y...)
Affinity DataIC50: 80nMpH: 7.5 T: 2°CAssay Description:The IDH1R132H protein and the IDH1R132C protein were prepared as follows: the IDH1R132H or IDH1R132C gene was integrated into a pET24b(+) vector (Nov...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent