BDBM278856 2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(3-chloro-1- methyl-1H-pyrazol- 4-yl)thieno[2,3-b] pyrazine-7- carboxamide trifluoroacetate::US10040802, Example 35

SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(N[C@@H]4CCCC[C@@H]4N)nc23)c(Cl)n1

InChI Key InChIKey=OBCIQLOOYAWCLX-VZXYPILPSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 278856   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM278856(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(3-chloro...)
Affinity DataIC50:  0.300nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent