BDBM279094 5-(2-ethoxy-3-pyridyl)-N-[(5-methoxy-3-pyridyl)methyl]-3-methyl-1-[1-methylpropyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 125::US10512632, Example 125::US10766893, Example S125::US10806718, Example 125::US11634416, Example 125

SMILES CCOc1ncccc1-c1cc(NCc2cncc(OC)c2)c2n(nc(C)c2n1)C(C)CC

InChI Key InChIKey=SYWOKLNWWYOPHL-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 279094   

LigandPNGBDBM279094(5-(2-ethoxy-3-pyridyl)-N-[(5-methoxy-3-pyridyl)met...)
Affinity DataIC50:  1nMpH: 7.6 T: 25°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279094(5-(2-ethoxy-3-pyridyl)-N-[(5-methoxy-3-pyridyl)met...)
Affinity DataIC50:  4.30nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279094(5-(2-ethoxy-3-pyridyl)-N-[(5-methoxy-3-pyridyl)met...)
Affinity DataIC50:  4.30nMpH: 7.6 T: 25°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279094(5-(2-ethoxy-3-pyridyl)-N-[(5-methoxy-3-pyridyl)met...)
Affinity DataIC50:  1nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279094(5-(2-ethoxy-3-pyridyl)-N-[(5-methoxy-3-pyridyl)met...)
Affinity DataIC50:  0.320nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279094(5-(2-ethoxy-3-pyridyl)-N-[(5-methoxy-3-pyridyl)met...)
Affinity DataIC50:  4.30nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279094(5-(2-ethoxy-3-pyridyl)-N-[(5-methoxy-3-pyridyl)met...)
Affinity DataIC50:  1nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279094(5-(2-ethoxy-3-pyridyl)-N-[(5-methoxy-3-pyridyl)met...)
Affinity DataIC50:  0.320nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279094(5-(2-ethoxy-3-pyridyl)-N-[(5-methoxy-3-pyridyl)met...)
Affinity DataIC50:  4.30nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279094(5-(2-ethoxy-3-pyridyl)-N-[(5-methoxy-3-pyridyl)met...)
Affinity DataIC50:  1nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279094(5-(2-ethoxy-3-pyridyl)-N-[(5-methoxy-3-pyridyl)met...)
Affinity DataIC50:  0.320nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279094(5-(2-ethoxy-3-pyridyl)-N-[(5-methoxy-3-pyridyl)met...)
Affinity DataIC50:  4.30nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279094(5-(2-ethoxy-3-pyridyl)-N-[(5-methoxy-3-pyridyl)met...)
Affinity DataIC50:  1nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279094(5-(2-ethoxy-3-pyridyl)-N-[(5-methoxy-3-pyridyl)met...)
Affinity DataIC50:  0.320nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279094(5-(2-ethoxy-3-pyridyl)-N-[(5-methoxy-3-pyridyl)met...)
Affinity DataIC50:  0.320nMpH: 7.6 T: 25°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent