BDBM279096 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-[(2-methyltetrazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 127::US10512632, Example 127::US10766893, Example S127::US10806718, Example 127::US11634416, Example 127

SMILES CCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)C(C)CC

InChI Key InChIKey=ULBLNKNNIPTFLN-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 279096   

LigandPNGBDBM279096(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  1.80nMpH: 7.6 T: 25°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279096(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  5.10nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279096(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  5.10nMpH: 7.6 T: 25°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279096(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  1.80nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279096(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  0.310nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279096(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  5.10nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279096(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  1.80nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279096(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  0.310nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279096(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  5.10nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279096(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  1.80nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279096(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  0.310nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279096(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  5.10nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279096(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  1.80nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279096(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  0.310nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM279096(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50:  0.310nMpH: 7.6 T: 25°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent