BDBM28119 3-cyanoquinoline, 4::4-({3-chloro-4-[(1-methyl-1H-imidazol-2-yl)sulfanyl]phenyl}amino)-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinoline-3-carbonitrile::CHEMBL323515

SMILES COc1cc2c(Nc3ccc(Sc4nccn4C)c(Cl)c3)c(cnc2cc1OCCCN1CCCC1)C#N

InChI Key InChIKey=YHAJJCOJWJKFSB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 28119   

TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM28119(3-cyanoquinoline, 4 | 4-({3-chloro-4-[(1-methyl-1H...)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration of the compound against Mitogen activated protein kinase kinase kinase 1 was determined using Raf/MEK1 coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28119(3-cyanoquinoline, 4 | 4-({3-chloro-4-[(1-methyl-1H...)
Affinity DataIC50:  88nMAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed