BDBM281356 6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-4-({2-[ethyl(methylsulfo-nyl)amino]ben-zyl}amino)-N-methyl-1H-pyrazolo[4,3-c]pyridine-3-carboxamide::US10022376, Example 9

SMILES CCN(c1ccccc1CNc1nc(cc2[nH]nc(C(=O)NC)c12)-c1cc(F)c(O)cc1CC)S(C)(=O)=O

InChI Key InChIKey=LNRYTDNWEWDQCY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 281356   

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandPNGBDBM281356(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-4-({2-[ethyl(...)
Affinity DataIC50: 1.70nMpH: 7.4 T: 2°CAssay Description:Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Pfizer

US Patent
LigandPNGBDBM281356(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-4-({2-[ethyl(...)
Affinity DataIC50: 7.20nMpH: 7.4 T: 2°CAssay Description:Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Pfizer

US Patent
LigandPNGBDBM281356(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-4-({2-[ethyl(...)
Affinity DataIC50: 10.8nMpH: 7.4 T: 2°CAssay Description:Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM281356(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-4-({2-[ethyl(...)
Affinity DataIC50: 60nMpH: 7.4 T: 2°CAssay Description:Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent