BDBM281416 6-[5-fluoro-4-hydroxy-2-(2,2,2-trifluoroeth-yl)phenyl]-4-({2-[(2-hydroxyethyl)(methyl-sulfonyl)amino]benzyl}amino)-1H-pyrazolo[4,3-c]pyridine-3-carboxamide::US10022376, Example 27

SMILES CS(=O)(=O)N(CCO)c1ccccc1CNc1nc(cc2[nH]nc(C(N)=O)c12)-c1cc(F)c(O)cc1CC(F)(F)F

InChI Key InChIKey=MERMSGBFNJYQKK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 281416   

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandPNGBDBM281416(6-[5-fluoro-4-hydroxy-2-(2,2,2-trifluoroeth-yl)phe...)
Affinity DataIC50: 2.90nMpH: 7.4 T: 2°CAssay Description:Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Pfizer

US Patent
LigandPNGBDBM281416(6-[5-fluoro-4-hydroxy-2-(2,2,2-trifluoroeth-yl)phe...)
Affinity DataIC50: 14.7nMpH: 7.4 T: 2°CAssay Description:Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Pfizer

US Patent
LigandPNGBDBM281416(6-[5-fluoro-4-hydroxy-2-(2,2,2-trifluoroeth-yl)phe...)
Affinity DataIC50: 48.8nMpH: 7.4 T: 2°CAssay Description:Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM281416(6-[5-fluoro-4-hydroxy-2-(2,2,2-trifluoroeth-yl)phe...)
Affinity DataIC50: 53.5nMpH: 7.4 T: 2°CAssay Description:Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent