BDBM281449 6-[5-fluoro-4-hydroxy-2-(2,2,2-trifluoroeth-yl)phenyl]-N-methyl-4-{[2-(sulfamoylmeth-yl)benzyl]amino}-1H-pyrazolo[4,3-c]pyridine-3-carboxamide::US10022376, Example 64

SMILES CNC(=O)c1n[nH]c2cc(nc(NCc3ccccc3CS(N)(=O)=O)c12)-c1cc(F)c(O)cc1CC(F)(F)F

InChI Key InChIKey=ALGHXSFRWUBSAW-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 281449   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM281449(6-[5-fluoro-4-hydroxy-2-(2,2,2-trifluoroeth-yl)phe...)
Affinity DataIC50:  3.30nMpH: 7.4 T: 2°CAssay Description:Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM281449(6-[5-fluoro-4-hydroxy-2-(2,2,2-trifluoroeth-yl)phe...)
Affinity DataIC50:  11.1nMpH: 7.4 T: 2°CAssay Description:Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM281449(6-[5-fluoro-4-hydroxy-2-(2,2,2-trifluoroeth-yl)phe...)
Affinity DataIC50:  36.9nMpH: 7.4 T: 2°CAssay Description:Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM281449(6-[5-fluoro-4-hydroxy-2-(2,2,2-trifluoroeth-yl)phe...)
Affinity DataIC50:  153nMpH: 7.4 T: 2°CAssay Description:Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM281449(6-[5-fluoro-4-hydroxy-2-(2,2,2-trifluoroeth-yl)phe...)
Affinity DataIC50:  3.30nMpH: 7.4 T: 2°CAssay Description:Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM281449(6-[5-fluoro-4-hydroxy-2-(2,2,2-trifluoroeth-yl)phe...)
Affinity DataIC50:  11.1nMpH: 7.4 T: 2°CAssay Description:Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM281449(6-[5-fluoro-4-hydroxy-2-(2,2,2-trifluoroeth-yl)phe...)
Affinity DataIC50:  36.9nMpH: 7.4 T: 2°CAssay Description:Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM281449(6-[5-fluoro-4-hydroxy-2-(2,2,2-trifluoroeth-yl)phe...)
Affinity DataIC50:  153nMpH: 7.4 T: 2°CAssay Description:Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent