BDBM282336 (S)-3-amino-6-(4-((5- cyano-3-(1-(4-fluorophenyl) ethylcarbamoyl)pyridin- 2-ylamino)methyl)phenyl)- N-methylpyrazine-2- carboxamide::US10030016, Example 216

SMILES CNC(=O)c1nc(cnc1N)-c1ccc(CNc2ncc(cc2C(=O)N[C@@H](C)c2ccc(F)cc2)C#N)cc1

InChI Key InChIKey=SVUOJPYVXJEKHM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 282336   

Target3-phosphoinositide-dependent protein kinase 1 [51-359](Human)
Sunesis Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 282336BDBM282336((S)-3-amino-6-(4-((5- cyano-3-(1-(4-fluorophenyl) ...)
Affinity DataIC50: 100nMAssay Description:PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent