BDBM282734 (R)-5-((4-Bromo-2,2-difluoro-3-hydroxy-1,1-dioxido- 2,3-dihydrobenzo[b]thiophen-5-yl)oxy)nicotinonitrile::US9884843, Compound 78

SMILES O[C@@H]1c2c(ccc(Oc3cncc(c3)C#N)c2Br)S(=O)(=O)C1(F)F

InChI Key InChIKey=PEZBSQNQKPICKG-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 282734   

TargetVascular endothelial growth factor A(Human)
Peloton Therapeutics

US Patent
LigandPNGBDBM282734(US9884843, Compound 78 | (R)-5-((4-Bromo-2,2-diflu...)
Affinity DataIC50: 120nMpH: 7.5Assay Description:The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2019
Entry Details
US Patent

TargetVascular endothelial growth factor A(Human)
Peloton Therapeutics

US Patent
LigandPNGBDBM282734(US9884843, Compound 78 | (R)-5-((4-Bromo-2,2-diflu...)
Affinity DataEC50:  330nMAssay Description:About 7500 of 786-O cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2019
Entry Details
US Patent