BDBM283559 N4-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 6-((3-chloroquinolin-6-yl)methyl)pyridine-2,4- dicarboxamide::US10023557, Example 208::US10023557, Example 209::US10308637, Example 208

SMILES Cc1cc(N)nc(C)c1CNC(=O)c1cc(Cc2ccc3ncc(Cl)cc3c2)nc(c1)C(N)=O

InChI Key InChIKey=APIQHIASTKZZSI-UHFFFAOYSA-N

Data  3 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 283559   

TargetPlasma kallikrein(Human)
Lifesci Pharmaceuticals

US Patent
LigandPNGBDBM283559(US10023557, Example 208 | US10023557, Example 209 ...)
Affinity DataIC50: 100nMpH: 7.5Assay Description:A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2019
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Lifesci Pharmaceuticals

US Patent
LigandPNGBDBM283559(US10023557, Example 208 | US10023557, Example 209 ...)
Affinity DataEC50: <100nMAssay Description:The test compounds at various concentrations, also prepared by serial dilutions as described above, are added to the test wells. The volume of test c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2019
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Lifesci Pharmaceuticals

US Patent
LigandPNGBDBM283559(US10023557, Example 208 | US10023557, Example 209 ...)
Affinity DataIC50: 100nMAssay Description:A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Lifesci Pharmaceuticals

US Patent
LigandPNGBDBM283559(US10023557, Example 208 | US10023557, Example 209 ...)
Affinity DataIC50: 100nMpH: 7.5Assay Description:A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2019
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Lifesci Pharmaceuticals

US Patent
LigandPNGBDBM283559(US10023557, Example 208 | US10023557, Example 209 ...)
Affinity DataEC50:  550nMAssay Description:The test compounds at various concentrations, also prepared by serial dilutions as described above, are added to the test wells. The volume of test c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2019
Entry Details
US Patent