BDBM284828 5-(6-(4-Amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)-1H-indazol-1-yl)-1-methylpyridin-2(1H)-one (18), and 5-(6-(4-Amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)-1H-indazol-1-yl)-1-methylpiperidin-2-one (19)::US10023576, Example 18::US10023576, Example 19

SMILES CN1CC(CCC1=O)n1ncc2ccc(cc12)-c1cc(-c2ccnn2C2CCOCC2)c2c(N)ncnn12

InChI Key InChIKey=ZMHALQKLJHKJBS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 284828   

LigandPNGBDBM284828(US10023576, Example 18 | 5-(6-(4-Amino-5-(1-(tetra...)
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
US Patent

LigandPNGBDBM284828(US10023576, Example 18 | 5-(6-(4-Amino-5-(1-(tetra...)
Affinity DataIC50: 4nMpH: 7.5 T: 2°CAssay Description:The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
US Patent