BDBM284899 (R)-1-(4-(4-amino-5-(1-(1,1,1- trifluoropropan-2-yl)-1H-pyrazol-5- yl)pyrrolo[2,1-f][1,2,4]triazin-7- yl)pyridin-2-yl)-4- (cyclopropanecarbonyl)-3,3- dimethylpiperazin-2-one::US10023576, Example 90

SMILES C[C@@H](n1nccc1-c1cc(-c2ccnc(c2)N2CCN(C(=O)C3CC3)C(C)(C)C2=O)n2ncnc(N)c12)C(F)(F)F

InChI Key InChIKey=SLTQFYWHSICOSK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 284899   

LigandPNGBDBM284899(US10023576, Example 90 | (R)-1-(4-(4-amino-5-(1-(1...)
Affinity DataIC50: 1nMpH: 7.5 T: 2°CAssay Description:The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
US Patent