BDBM284974 4-(3,4-dihydro-2H-1,4-benzoxazin-6-yl)-2- methylisoquinolin-1-one::US10023592, Example 19::US10941160, Example 19

SMILES Cn1cc(-c2ccc3OCCNc3c2)c2ccccc2c1=O

InChI Key InChIKey=AVRQZBKJBDYYDC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 284974   

TargetBromodomain-containing protein 4(Human)
Celgene Quanticel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 284974BDBM284974(US10023592, Example 19 | 4-(3,4-dihydro-2H-1,4-ben...)
Affinity DataIC50: 2.75E+3nMAssay Description:Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BRD4 was cloned, expr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetBromodomain-containing protein 4(Human)
Celgene Quanticel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 284974BDBM284974(US10023592, Example 19 | 4-(3,4-dihydro-2H-1,4-ben...)
Affinity DataIC50: 2.75E+3nMpH: 7.3Assay Description:Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BRD4 was cloned, expr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
US Patent