BDBM285045 4-[2-(cyclopropylmethoxy)-5- methylsulfonylphenyl]-6-fluoro-2- methylisoquinolin-1-one::BDBM485889::US10023592, Example 90

SMILES Cn1cc(-c2cc(ccc2OCC2CC2)S(C)(=O)=O)c2cc(F)ccc2c1=O

InChI Key InChIKey=YZOPGLSDJSTSFD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 285045   

TargetBromodomain-containing protein 4(Human)
Celgene Quanticel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 285045BDBM285045(4-[2-(cyclopropylmethoxy)-5- methylsulfonylphenyl]...)
Affinity DataIC50: 500nMAssay Description:Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BRD4 was cloned, expr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetBromodomain-containing protein 4(Human)
Celgene Quanticel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 285045BDBM285045(4-[2-(cyclopropylmethoxy)-5- methylsulfonylphenyl]...)
Affinity DataIC50: 500nMpH: 7.3Assay Description:Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BRD4 was cloned, expr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
US Patent