BDBM28543 N,3-dimethyl-11-phenyl-1,3,5,8,12-pentaazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),4,7,9,11-pentaen-7-amine::pyrazolopurine, 3b

SMILES CNc1nc2cc(nn2c2n(C)cnc12)-c1ccccc1

InChI Key InChIKey=SKZBDNWUNUGWAT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 28543   

TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM28543(N,3-dimethyl-11-phenyl-1,3,5,8,12-pentaazatricyclo...)
Affinity DataIC50: 34nMAssay Description:Inhibition of human IKKbeta using GST-IkappaBalpha as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM28543(N,3-dimethyl-11-phenyl-1,3,5,8,12-pentaazatricyclo...)
Affinity DataIC50: 34nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2009
Entry Details Article
PubMed
LigandPNGBDBM28543(N,3-dimethyl-11-phenyl-1,3,5,8,12-pentaazatricyclo...)
Affinity DataIC50: 990nMT: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2009
Entry Details Article
PubMed