BDBM28561 N-ethyl-4-(4-fluorophenyl)-12-methyl-5-thia-3,7,10,12-tetraazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2(6),3,7,10-pentaen-8-amine::thiazole-based tricyclic inhibitor, 32b

SMILES CCNc1nc2sc(nc2c2n(C)cnc12)-c1ccc(F)cc1

InChI Key InChIKey=BNNHUJVLSQMBPR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 28561   

TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM28561(N-ethyl-4-(4-fluorophenyl)-12-methyl-5-thia-3,7,10...)
Affinity DataIC50: 39nMAssay Description:Inhibition of human IKKbeta using GST-IkappaBalpha as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM28561(N-ethyl-4-(4-fluorophenyl)-12-methyl-5-thia-3,7,10...)
Affinity DataIC50: 39nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2009
Entry Details Article
PubMed
LigandPNGBDBM28561(N-ethyl-4-(4-fluorophenyl)-12-methyl-5-thia-3,7,10...)
Affinity DataIC50: 3.40E+3nMT: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2009
Entry Details Article
PubMed