BDBM28571 N-({3-[12-methyl-8-(methylamino)-5-thia-3,7,10,12-tetraazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2(6),3,7,10-pentaen-4-yl]phenyl}methyl)-1,2,3-thiadiazole-4-carboxamide::thiazole-based tricyclic inhibitor, 36d

SMILES CNc1nc2sc(nc2c2n(C)cnc12)-c1cccc(CNC(=O)c2csnn2)c1

InChI Key InChIKey=IXXYZROLDGZZKB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 28571   

LigandPNGBDBM28571(N-({3-[12-methyl-8-(methylamino)-5-thia-3,7,10,12-...)
Affinity DataIC50: 16nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2009
Entry Details Article
PubMed
LigandPNGBDBM28571(N-({3-[12-methyl-8-(methylamino)-5-thia-3,7,10,12-...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human IKKbeta using GST-IkappaBalpha as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
LigandPNGBDBM28571(N-({3-[12-methyl-8-(methylamino)-5-thia-3,7,10,12-...)
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2009
Entry Details Article
PubMed