BDBM287036 6-[5-fluoro-4-hydroxy-2-(2,2,2-trifluoroethyl)phenyl]-4-({2-[(2-hydroxyethyl)(methylsul-fonyl)amino]benzyl}amino)-1H-pyrazolo[4,3-c]pyridine-3-carboxamide::US9518052, Example 27

SMILES CS(=O)(=O)N(CCO)c1ccccc1CNc1nc(cc(N)c1C(=N)C(N)=O)-c1cc(F)c(O)cc1CC(F)(F)F

InChI Key InChIKey=ZNVOURRPUATFRP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 287036   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM287036(6-[5-fluoro-4-hydroxy-2-(2,2,2-trifluoroethyl)phen...)
Affinity DataIC50:  2.90nMpH: 7.4 T: 2°CAssay Description:Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM287036(6-[5-fluoro-4-hydroxy-2-(2,2,2-trifluoroethyl)phen...)
Affinity DataIC50:  48.8nMpH: 7.4 T: 2°CAssay Description:Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM287036(6-[5-fluoro-4-hydroxy-2-(2,2,2-trifluoroethyl)phen...)
Affinity DataIC50:  53.5nMpH: 7.4 T: 2°CAssay Description:Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM287036(6-[5-fluoro-4-hydroxy-2-(2,2,2-trifluoroethyl)phen...)
Affinity DataIC50:  14.7nMpH: 7.4 T: 2°CAssay Description:Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent