BDBM288178 (1R,2R)-N-(3-chloro-2- fluorobenzyl)-2'-ethyl-9'- hydroxy-2-(hydroxymethyl)- 1',8'-dioxo-1',2',4',8'- tetrahydrospiro[cyclopropane- 1,3'-pyrido[1,2-a]pyrazine]- 7'-carboxamide hydrochloride::US10087178, Example T46

SMILES CCN1C(=O)c2c(O)c(=O)c(cn2C[C@]11C[C@H]1CO)C(=O)NCc1cccc(Cl)c1F

InChI Key InChIKey=QNTMXNFLDFLQOS-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 288178   

TargetProtein Nef(HIV-1)
Japan Tobacco

US Patent
LigandPNGBDBM288178((1R,2R)-N-(3-chloro-2- fluorobenzyl)-2'-ethyl-9'- ...)
Affinity DataEC50:  3.40nMT: 2°CAssay Description:The medium (40 μL), a test substance (10 μL) diluted with the medium, and a 1×105 cells/mL MT-4 cell suspension (50 μL) wherein HIV-1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent