BDBM288892 US10092563, Compound 27

SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1C1CCCNC1

InChI Key InChIKey=CTEDAXMSXGMIPR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 288892   

LigandPNGBDBM288892(US10092563, Compound 27)
Affinity DataIC50: 8.30E+5nMpH: 7.4Assay Description:TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2019
Entry Details
US Patent

TargetPhosphatidylinositol 3-kinase regulatory subunit beta(Human)
Gilead Sciences

US Patent
LigandPNGBDBM288892(US10092563, Compound 27)
Affinity DataIC50: 5.60E+6nMpH: 7.4Assay Description:TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2019
Entry Details
US Patent

LigandPNGBDBM288892(US10092563, Compound 27)
Affinity DataIC50: 1.00E+7nMpH: 7.4Assay Description:TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2019
Entry Details
US Patent