BDBM289116 N-(4-(1H-1,2,3-triazol-5-yl)phenyl)-6-hydroxy-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide::US10093658, Compound Formula (IIf)

SMILES Oc1[nH]c(=S)[nH]c(=O)c1C(=O)Nc1ccc(cc1)-c1cnn[nH]1

InChI Key InChIKey=HLSXOLJIERXFJC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 289116   

TargetXanthine dehydrogenase/oxidase(Human)
Acquist

US Patent
LigandPNGBDBM289116(US10093658, Compound Formula (IIf) | N-(4-(1H-1,2,...)
Affinity DataIC50: 60nMAssay Description:Xanthine oxidase inhibition was determined using a standard fluorescence-based assay for xanthine oxidase activity (McHale A, Grimes H, Coughlan M P:...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2019
Entry Details
US Patent

TargetXanthine dehydrogenase/oxidase(Human)
Acquist

US Patent
LigandPNGBDBM289116(US10093658, Compound Formula (IIf) | N-(4-(1H-1,2,...)
Affinity DataIC50: 90nMAssay Description:Xanthine oxidase inhibition was determined using a standard fluorescence-based assay for xanthine oxidase activity (McHale A, Grimes H, Coughlan M P:...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2019
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
Acquist

US Patent
LigandPNGBDBM289116(US10093658, Compound Formula (IIf) | N-(4-(1H-1,2,...)
Affinity DataIC50: 1.11E+4nMAssay Description:URAT1 (SLC22A12) activity was evaluated in a cellular uptake assay using a 96-well plate with stably transfected URAT-1/CHO cells. 3H-orotate was use...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2019
Entry Details
US Patent