BDBM289177 US10093660, Example 14.8::US10093660, Example 2.9

SMILES CO[C@@H]1COC[C@@H]1Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S(C)(C)=O

InChI Key InChIKey=OPCZBBDJOVZICW-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 289177   

TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Evotec Internatonal

US Patent
LigandPNGBDBM289177(US10093660, Example 2.9 | US10093660, Example 14.8)
Affinity DataIC50: 1nMT: 2°CAssay Description:ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2019
Entry Details
US Patent

TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Evotec Internatonal

US Patent
LigandPNGBDBM289177(US10093660, Example 2.9 | US10093660, Example 14.8)
Affinity DataIC50: 4nMT: 2°CAssay Description:ASSAY SETUP: The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2019
Entry Details
US Patent

TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Evotec Internatonal

US Patent
LigandPNGBDBM289177(US10093660, Example 2.9 | US10093660, Example 14.8)
Affinity DataIC50: 80nMAssay Description:MNK1 Data can be obtained from the MNK1 Z′-LYTE assay. The MNK1 Z′-LYTE screening protocol and assay conditions are also described on www...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2019
Entry Details
US Patent

TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Evotec Internatonal

US Patent
LigandPNGBDBM289177(US10093660, Example 2.9 | US10093660, Example 14.8)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Mnk2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Evotec Internatonal

US Patent
LigandPNGBDBM289177(US10093660, Example 2.9 | US10093660, Example 14.8)
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of Mnk1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed