BDBM289303 1-{1-[4,5-Dichloro-2-methoxy-3- (1-oxetan-3-ylazetidin-3- yl)phenyl]ethyl}-3-methyl-1H- pyrazolo[3,4-d]pyrimidin-4-amine (peak 1)3::US10092570, Example 304::US10376513, Example 304::US10646492, Example 304::US11433071, Example 304::US9730939, Example 304

SMILES COc1c(cc(Cl)c(Cl)c1C1CN(C1)C1COC1)C(C)n1nc(C)c2c(N)ncnc12

InChI Key InChIKey=JUIUKAYNNVNLFM-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 289303   

LigandPNGBDBM289303(1-{1-[4,5-Dichloro-2-methoxy-3- (1-oxetan-3-ylazet...)
Affinity DataIC50: 10nMAssay Description:The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2022
Entry Details
US Patent

LigandPNGBDBM289303(1-{1-[4,5-Dichloro-2-methoxy-3- (1-oxetan-3-ylazet...)
Affinity DataIC50: 10nMpH: 6.7 T: 2°CAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2019
Entry Details
US Patent

LigandPNGBDBM289303(1-{1-[4,5-Dichloro-2-methoxy-3- (1-oxetan-3-ylazet...)
Affinity DataIC50: 10nMAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

LigandPNGBDBM289303(1-{1-[4,5-Dichloro-2-methoxy-3- (1-oxetan-3-ylazet...)
Affinity DataIC50: 10nMAssay Description:The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
US Patent

LigandPNGBDBM289303(1-{1-[4,5-Dichloro-2-methoxy-3- (1-oxetan-3-ylazet...)
Affinity DataIC50: 10nMAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent