BDBM289307 4-[1-(4-Amino-5-methyl-7H- pyrrolo[2,3-d]pyrimidin-7- yl)ethyl]-6-chloro-3-ethoxy-2-[1- (2-hydroxyethyl)azetidin-3-yl]benzonitrile3::US10092570, Example 308::US10646492, Example 300::US11433071, Example 300::US9730939, Example 300

SMILES COc1c(cc(Cl)c(Cl)c1C1CN(CCO)C1)C(C)n1nc(C)c2c(N)ncnc12

InChI Key InChIKey=IRSHORZQIUSICQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 289307   

LigandPNGBDBM289307(4-[1-(4-Amino-5-methyl-7H- pyrrolo[2,3-d]pyrimidin...)
Affinity DataIC50: 10nMAssay Description:The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2022
Entry Details
US Patent

LigandPNGBDBM289307(4-[1-(4-Amino-5-methyl-7H- pyrrolo[2,3-d]pyrimidin...)
Affinity DataIC50: 10nMAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

LigandPNGBDBM289307(4-[1-(4-Amino-5-methyl-7H- pyrrolo[2,3-d]pyrimidin...)
Affinity DataIC50: 10nMpH: 6.7 T: 2°CAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2019
Entry Details
US Patent

LigandPNGBDBM289307(4-[1-(4-Amino-5-methyl-7H- pyrrolo[2,3-d]pyrimidin...)
Affinity DataIC50: 10nMAssay Description:The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
US Patent