BDBM28931 (2S,3S)-N-(4-cyanophenyl)-1-hydroxy-3-methylpentane-2-sulfonamido::phenylsulfonamide, 2f

SMILES CC[C@@H](Nc1cc(F)c(C(=O)N[C@@H](Cc2ccc(-c3c(C(F)(F)F)c4ccncc4n(C)c3=O)c3ncccc23)C(=O)O)c(F)c1)C(F)(F)F

InChI Key InChIKey=YZUXEUMOSYLXGH-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 28931   

TargetIntegrin alpha-4/beta-7(Human)
GILEAD SCIENCES, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 28931BDBM28931(US11116760, Example 111)
Affinity DataEC50:  0.100nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2026
Entry Details US Patent