BDBM289322 4-[1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]pyrimidin-1- yl)ethyl]-6-chloro-3-ethoxy-2- pyrimidin-5-ylbenzonitrile2::US10092570, Example 329::US11433071, Example 329

SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)c1cncnc1)C(C)n1nc(C)c2c(N)ncnc12

InChI Key InChIKey=HZBCOYGCTZNJOE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 289322   

LigandPNGBDBM289322(4-[1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]pyrimidi...)
Affinity DataIC50: 10nMAssay Description:The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2022
Entry Details
US Patent

LigandPNGBDBM289322(4-[1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]pyrimidi...)
Affinity DataIC50: 10nMpH: 6.7 T: 2°CAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2019
Entry Details
US Patent